Combine Effect of Vitamin C and venlafaxine on the Amino Acid Content of Saccharomyces cerevisiae
DOI:
https://doi.org/10.14738/aivp.96.11207Keywords:
S. cerevisiae, Venlafaxine, Vitamin C, Amino acidAbstract
In this study, Saccharomyces cerevisiae (NRLLY-12632) was grown in YPD medium containing different concentrations of venlafaxine, (RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl] cyclohexanol. To counteract the effect of venlafaxine, vitamin C were added to the growth medium of S. cerevisiae, and amino acids content were investigated by HPLC. It was observed that, the amount of amino acids in S. cerevisiae grown in YPD medium, containing 100, 200, 300, 400 and 500 ppm venlafaxine were compared with the control, the amounts of alanine, arginine, asparagine, aspartic acid, cysteine, glycine, histidine, isoleucine, leucine, lysine, phenylalanine, proline, threonine, tyrosine and valine increased (p<0.05), glutamic acid, glutamine, methionine, serine and tryptophan levels were decreased p<0.05). With the addition of vitamin C to the growth medium containing venlafaxine, all the amino acids concentrations get close to the control group. From these findings, it can be said that the negative effect of venlafaxine on S. cerevisiae is reduced by the addition of vitamin C to the medium.
References
. Herskowitz, I. Life Cycle of the Budding Yeast Saccharomyces cerevisiae, Microbiology Reviews, 1988. 52(4): p. 536–553.
. Gil-rodriguez, A.M., A.V. Carrascosa, and T. Requena, Yeasts in foods and beverages: In vitro characterisation of probiotic traits, LWT - Food Science and Technology, 2015. 64(2): p 1156– 1162.
. Albergaria, H., N. Arneborg, Dominance of Saccharomyces cerevisiae in alcoholic fermentation processes: role of physiological fitness and microbial interactions, Applied Microbiology Biotechnology, 2016. 100: p. 2035–2046
. Gadassi, R., N. Mor, Confusing acceptance and mere politeness: Depression and sensitivity to Duchenne smiles, Journal of Behavior Therapy and Experimental Psychiatry, 2016. 50: p. 8-14
. Yüzbaşıoğlu, D., Y.E. Avuloğlu, F. Ünal, Antidepresan İlaçlar ve Genotoksisite, Türk Bilim Araştırma Vakfı, 2016. 9 (1): p. 17-28
. Albayrak, Y., M. Kuloğlu,. Antidepresanlar ve Akatizi, Journal of Mood Disorders, 20133(4):p. 162-170.
. Möller, H.J., et al., Position statement of the European Psychiatric Association (EPA) on the value of antidepressants in the treatment of unipolar depression, European Psychiatry, 2012. 27: p.114-128.
. Çetin, M., C. Açıkel, Meta-analizler ışığında: bütün antidepresanlar aynı mıdır?” Klinik Psikofarmakoloji Bülteni, 2009. 19: p. 87-92.
. Hassanane, M.S., et al., Genotoxic evaluation for the tricyclic antidepressant drug, amitriptyline, Drug and Chemical Toxicology, 2012. 35(4): p. 450-455.
. Devaki, S.J., R.L. Raveendran, Vitamin C: Sources, Functions, Sensing and Analysis. INTECH 2017. http://dx.doi.org/10.5772/intechopen.70162
. Neuberg, M., et al., The effect of different nitrogen nutrition on praline and asparagine content in plant, Plant Soil and Environment, 2010. 56: p. 305–311
. Wu, G. Functional amino acids in nutrition and health, Amino Acids, 2013. 45(3): p. 407–411.
. Su, L., et al., Dynamic changes in amino acid concentration profiles in patients with sepsis, PLoS One, 2015. 10(4): e0121933.
. Gu, Y., et al., Perioperative dynamics and significance of amino acid profiles in patients with cancer, Journal of Translation Medicine, 2015. 13(35): p. 1–14
. Elkin, R.G., A.M. Wasynczuk, Amino Acid Analysis of Feedstuff Hydrolysates by Precolumn Derivatization with Phenylisothiocyanate and Reversed-Phase High-Performance Liquid Chromatography, Cereal Chemistry, 1987. 64(4): p. 226-229.
. Kwanyuen, P., J.W. Burton, A Modified Amino Acid Analysis Using PITC Derivatization for Soybeans with Accurate Determination of Cysteine and Half-Cystine, Journal of the American Oil Chemists' Society, 2010. 87(2): p. 127–132.
. Wu, G. Functional amino acids in growth, reproduction, and health, Advances in Nutrition, 2010. 1: p.31-37
. Alreshidi, M.M., et al., Amino acids and proteomic acclimation of Staphylococcus aureus when incubated in a defined minimal medium supplemented with 5% sodium chloride, Microbiologyopen, 2019. 8(6): p. 1-10, e00772.
. Xu, J., et al., Comparative transcriptome analysis of cadmium responses in Solanum nigrum and Solanum torvum, New Phytologist, 2012. 196(1): p. 110–124.
. Zemanova, V., M, Pavlik, and D. Pavlikova, Cadmium toxicity induced contrasting patterns of concentrations of free sarcosine, specific amino acids and selected microelements in two Noccaea species, Plos One, 2017. 12(5): p. 1-17. e0177963.
. Sanchez, F.J., et al., Turgor maintenance, osmotic adjustment and soluble sugar and proline accumulation in 49 pea cultivars in response to water stressʺ. Field Crops Research, 1998. 59(3): p. 225-235.
. Kalefetoğlu, T., Y. Ekmekçi, Bitkilerde kuraklık stresinin etkileri ve dayanıklılık, G.U. Journal of Science, 2005. 18(4): p 723-740.
. Yang, H.Q., H.J. Gao, Physiological function of arginine and its metabolites in plants, Journal of Plant Physiology and Molecular Biology, 2007. 33(1): p. 1-8.
. Haroun, S.A., W.M. Shukry, and O. El-Sawy, Effect of asparagine or glutamine on growth and metabolic changes in phaseolus vulgaris under in vitro conditions, Bioscience Research, 2010. 7(1): p. 1-21.
. Chen, T.H., N. Murata, Glycinebetaine: an effective protectant against abiotic stress in plants, Trends of Plant Science, 2008. 13(9): p. 499-505.
. Olgun, M., et al., Potasyum Iyodür Uygulamasının Ekmeklik Buğday Çeşitlerinin Biyokimyasal Özellikleri Üzerine Etkisi, Süleyman Demirel Üniversitesi Ziraat Fakültesi Dergisi, 2016. 11 (2): p. 46-60.
. Ros, R., J.M. Bertomeu, and S. Krueger, Serine in plants: biosynthesis, metabolism, and functions, Trends in Plant Science, 2014. 19(9): p. 564-569.
. Pavlíková, D., et al., Glutamate kinase as a potential biomarker of heavy metal stress in plants, Ecotoxicology and Environmental Safety, 2008. 70(2): p. 223-230.
. Joshi, V., et al., Interdependence of threonine, methionine and isoleucine metabolism in plants: accumulation and transcriptional regulation under abiotic stress, Amino Acids, 2010. 39(4): p. 933-947.
. Fersht, A. Structure and Mechanism in Protein Science. W.H. Freeman and Company; New York. 1999. "
. Tohge, T., et al., Shikimate and phenylalanine biosynthesis in the green lineage, Frontiers in Plant Science, 2013. 4: p. 1-14
. Azevedo, R.A., P.J. Lea, Lysine metabolism in higher plants, Amino Acids, 2001. 20(3): p. 261-279.
. Singhl, B.K., D.L. Shaner, Biosynthesis of branched chain amino acids: From test tube to field, The Plant Cell, 1995. 7: P. 935-944.
. Forde, B.G., J.F. Lea, Glutamate in plants: metabolism, regulation, and signalling, Journal of Experimental Botany, 2007. 58(9): p. 2339-2358.
. Ghelis, T. Signal processing by protein tyrosine phosphorylation in plants, Plant Signaling & Behavior, 2011. 6(7): p. 942-951.
. Miflin, B.J., D.Z. Habash, The role of glutamine synthetase and glutamate dehydrogenase in nitrogen assimilation and possibilities for improvement in the nitrogen utilization of crops, Journal of Experimental Botany, 2002. 53(370): p. 979- 987.
. Michel, N.A., et al., Study of the Physicochemical Properties, The Anti-Nutrient, Antioxidant and Mineral Composition of Capsicum Annuum Chili Pepper Sold in the Three (3) Main Markets of Korhogo, in the North of Côte d’Ivoire, European Journal of Applied Sciences, 2021. 9(4): p.94–107.
. Bettina; M., et al., The role of vitamin C in stress-related disorders, The Journal of Nutritional Biochemistry, 2020. (), 108459: p. 1-18.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Dursun Özer, Fikret Karataş, Meltem Çakmak; Sinan SAYDAM
This work is licensed under a Creative Commons Attribution 4.0 International License.
