Effect of Carp Glycophorin as an Antibiotic Reagent: Application of Carp Glycophorin from Red Blood Cell (RBC) Membranes as an Antibiotic Reagent

Authors

  • Takahiko Aoki Laboratory of Quality in Marine Products, Graduate School of Bioresources, Mie University, 1577 Kurima Machiya-cho, Tsu, Mie 514-8507, Japan
  • Takeshi Kurimoto Laboratory of Quality in Marine Products, Graduate School of Bioresources, Mie University, 1577 Kurima Machiya-cho, Tsu, Mie 514-8507, Japan
  • Taisuke Inoue Laboratory of Quality in Marine Products, Graduate School of Bioresources, Mie University, 1577 Kurima Machiya-cho, Tsu, Mie 514-8507, Japan
  • Hikaru Sugiura Laboratory of Quality in Marine Products, Graduate School of Bioresources, Mie University, 1577 Kurima Machiya-cho, Tsu, Mie 514-8507, Japan

DOI:

https://doi.org/10.14738/aivp.114.15292

Keywords:

Fish, Carp, Red Blood Cell Membranes, Glycophorin, Antibiotic Reagent

Abstract

Carp red blood cell (RBC) membranes contain a glycophorin (GP) that is responsive to a carp pathogen.　The efficacy of carp GP as an antibacterial reagent was evaluated for the control of disease in rainbow trout (Oncorhynchus mykiss). The results suggest that intravenous administration of GP significantly delays the time of death following challenge with Vibrio anguillarum. In addition, we showed that carp GP was effective at adsorbing V. anguillarum and Micrococcus luteus from suspension following GP-binding column chromatography. After conducting small column experiments, we performed an upscaling column attached to a 500 L water tub with Escherichia coli.

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Published

2023-08-20

How to Cite

Aoki, T., Kurimoto, T., Inoue, T., & Sugiura, H. (2023). Effect of Carp Glycophorin as an Antibiotic Reagent: Application of Carp Glycophorin from Red Blood Cell (RBC) Membranes as an Antibiotic Reagent. European Journal of Applied Sciences, 11(4), 246–254. https://doi.org/10.14738/aivp.114.15292

Issue

Vol. 11 No. 4 (2023): European Journal of Applied Sciences

Section

Articles

License

Copyright (c) 2023 Takahiko Aoki, Takeshi Kurimoto, Taisuke Inoue, Hikaru Sugiura

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.