The Antifungal Activities of Plumbago zeylanica Extract against Aspergillus flavus, Lasiodiplodia theobromae and Cladosporium oxysporum for Potential Human Cream Development
DOI:
https://doi.org/10.14738/aivp.91.9129Abstract
The experimental study was carried out to evaluate the antifungal activities of Plumbago zeylanica Extract against Lasiodiplodia (Oncobasidium) theobromae, Cladosporum oxysporum and Aspergillus flavus for medical purposes. A standard extraction procedure of the plant leaf and preparation of test microorganisms was carried out. The rate of mycelial growth inhibition of the microorganisms measured at different concentrations of 12.5 mg/ml, 25 mg/ml, 50 mg/ml and100 mg/ml over a period of 48 - 120 hours showed that the extract has significant antifungal effects on the three fungal species; with indications of positive manifestations of the extract on the test pathogens at different tested hours and all the fungi pathogens were found susceptible at different hours of incubation. Furthermore, the high percentage inhibition for the three fungi mostly at 50 mg/ml and 100 mg/ml concentrations shows that Plumbago zeylanica leaf extract contains very active ingredients in the control of fungal diseases. Then, further studies will be carried out for the development of potential antifungal cream that can be applied on human skins.
References
(1) Savita, J. and S.C Sati, Antibacterial Activity of Methanol and Chloroform Extracts of Himalayan Gymnosperms Plant Cedrus deodara Roxb 2012 Proc. 99th ISC 2012; Sec. XIV Pl. Sciences.
(2) Bajpayaee, K.K., and A. Bajpai, Antifungal Activities of Leaf Extract of Calotropis procera (Ait) R.Br. (asclepiadaceae) 2012 Proc. 99th ISC 2012; Sec. XIV Pl. Sciences.
(3) Golshani, Z., and P.I.P Ali Sharifzadeh, Evaluation of Antibacterial Activity of Alcoholic Extract of Rosemary Leaves against Pathogenic Strains. Zahedan University of Medical Sciences 2013
(4) Sharma, I., et al., Hypolipidemic and antiatherosclerotic effects of plumbagin in rabbits. Indian Journal of Physiology and pharmacology 1991. 35(1): p 10- 14.
(5) Oyedapo, O. O, Studies on the bioactivity of the extract of Plumbago zeylanica. Phytotherapy Research 1996. 13: p. 346-348.
(6) Mehmood, Z., et al., Indian Midicinal plant: A potential source for anticandidal drug. Pharmaceutical Biology 1999. 37(3): p. 237-242.
(7) Ahmad, I., et al., Antimicrobial potency and synergistic activity of five traditionally used Indian Medicinal plants. Medicinal and Aromatic plant Sciences 2000. 23: p.173-176.
(8) Simonsen, H.T., et al., In vitro Screening of Indian medicinal plants for antiplasmodial activity. Ethnopharmacology 2001.74: p 195-204.
(9) Nisha, S. and K. Purshotam, Medicinal, Biological and Pharmacological Aspects of Plumbago zeylanica (Linn.) Pharmacognosy and Phytochemistry 2014. 3(4): p. 117-120.
(10) Adegbite, A.A., et al., Antimicrobial Activity of Plumbago zeylanica Plant Extracts and Its Application in Water and Laboratory Disinfection. American Academic and Scholarly Research 2015. 6(6): p 55-63.
(11) Adebanjo, A., et al., Evaluation of Acute Toxicity of Plumbago zeynalica extracts on the skin of rats. African Journal of Water and Health. 2 (1): p 24-27
(12) Jeum, K. H., et al., Application of Volatile Antifungal Plant Essential Oils for Controlling Pepper Fruit Anthracnose by Colletotrichum gloeosporioides. Plant Pathol. 2015. 31(3): p.269-277
